2010•Chinese Journal of Integrated Traditional and Western NephrologyRequires access
The Protective Effects of Putian Capsule on Renal Ischemia Reperfusion Injury (I/R) Rats Models
Rui Ding
Open publisher page 1 citations
Abstract
Objective:To explore the protective effects of Putian capsule on renal ischemia reperfusion injury(I/R)rats models.Methods:Twenty-four Wistar male rats were divided evenly into 3 groups randomly:the Sham-operated group(group Sham),the renal ischemia reperfusion injury group(group I/R)and the Putian preconditioning group(group PT).The rats in group I/R and PT were made I/R models by operation and the ischemia time was 1 hour.The PT group were treated by PT 160 mg·kg-1·d-1 before the operation.The levels of serum creatinine(Scr),blood urea nitrogen(BUN)and albumin(Alb)were detected respectively at 24,48 and 72 hour after ischemia and reperfusion(I/R)happened.Pathological changes in the different time were also noted by light microscope.Results:Compared with those in the sham group,the Scr and BUN were much higher in the control group after I/R at 24,48 and 72 hour,while these were not significantly elevated in PT group.The renal pathological changes were more severe in the model group than that of PT group.Conclusion:The results demonstrated that Putian capsule could protect the renal function against renal ischemia reperfusion injury and it could be used as a valuable clinical product.