2013•Chinese journal of integrated traditional and Western medicineRequires access
Efficacy of telbivudine treatment of patients with HBeAg-positive chro nic hepatitis B for 52 weeks
XU Jian-qiu
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Abstract
Objective: To evaluate the efficacy of telbivudine treatment of patients with HBeAg-positive chronic hepatitis B for 52 weeks.Methods: Eighty-two patients treated with telbivudine 600mg qd PO for 52 weeks were enrolled.The rates of HBV DNA undetectable,ALT normalizition,HBeAg loss and seroconversion were compared before and after 4,12,24,36,48,52 weeks of treatment.Results: Compared with before treatment,the rates of HBV DNA undetectable,ALT normalizition at after 4 weeks and HBeAg loss at after 12 weeks,HBeAg seroconversion at after 36 weeks were significantly higher(P 0.05),the rates were 95.12%,95.12%,56.1%,32.93% respectly at 52 weeks.Conclusion: Telbivudine is effective in patients with chronic hepatitis B.