Prophylactic and therapeutic effect of rosiglitazone on acute necrotic pancreatitis(ANP) and pancreatitis associated pulmonary injury

Objective To study the protective effect of rosiglitazone(ROSI) on acute necrotic pancreatitis(ANP) and pancreatitis associated pulmonary injury.Methods 40 Sprague Dawley(SD) rats were randomly divided into ANP group,prophylactic group,therapeutic group and control group,10 cases of each.ANP group was given intraperitoneal injection of L-arginine to induce ANP model;The prophylactic group was given ROSI before inducing ANP model;The therapeutic group was given ROSI after induction of ANP model;The control group was injected into the same volume of 0.9% saline solution.Observed the amylase(AMY),TNF-α,IL-1β,resistin,Hs-CRP in serum,and myeloperoxidase(MPO) activity,wet/dry ratio(W/D) were evaluated.Results The levels of serum AMY,TNF-α,IL-1β,resistin,Hs-CRP,lung MPO,W/D ratio in ANP group were significantly higher than those of the control group(P 0.01) ;Compared with those of ANP group,the levels of serum AMY,TNF-α,IL-1β,resistin,Hs-CRP,lung MPO,W/D ratio of prophylactic and therapeutic group were significantly lower(P 0.01),while pancreatic and pulmonary pathological injury significantly reduced(P 0.01).Conclusion ROSI can significantly reduce the inflammation of ANP,and also have protective and remedial function on ANP and pancreatitis associated pulmonary injury.