18F-FDG PET/CT Compare with CT on Evaluating Chemotherapy Reaction in Treatment Early Cisplatin in Solid Tumer in Rabbits

Objective To explore the feasibility of using 18F-FDG PET/CT as an in vivo individual chemosensitivity testing method.Methods Twenty-eight VX2 rabbits were randomized into treatment group and control group.The first 18F-FDG PET/CT was performed the day before intravenous administration of cisplatin(6mg/kg) and the second was 36 hours later.In the experimental groups,cisplatin administration was 4 hours,24 hours and 36 hours before the second PET/CT imaging.The control group,without cisplatin administration,received the 18F-FDG PET/CT imaging at the same time points.Maximum standardized uptake value(SUVmax) was analyzed.Tumor volume was defined in CT images.Results The results showed that there is a significant difference(P0.05) in SUVmax on hour 4 between it and the control group,with SUVmax decrease rate of(-11.11±13.13)%.On hour 24,a significant difference in SUVmax was observed between it and the control grou,(P0.05)with SUV decrease rate of(-37.33±12.58)%.The results also showed a significant difference(P0.05) in SUVmax on hour36 between the group and the control group,with SUVmax decrease rate of(-34.21±12.93)%.No significant difference in tumor volume was found between the three experimental groups and the control group(P0.05).Conclusion The study showed that 18F-FDG PET/CT can be used as an in vivo chemosensitivity testing method.According to the decrease rate when cisplatin adminstration,PET/CT can early in vivo sensitively differentiate the sensitive and insensitive tumors.