Changes of Plasma MOT and Antroduodenal SP Expression in Rats with Functional Dyspepsia and Effect of Qingzhishu

objective: To investigate the antroduodenal motility, MOT and SP expression changes in rats with functional dyspepsia (FD) (type of incoordination between the liver and stomach) and to illustrate the possible mechanism of Qingzhishus effect. Methods: All rats were divided into 4 groups at random. The rat models of incoordination between the liver and stomach in FD were induced by stimulating the tails of the rats. Rats were implanted with strain gauges in the gastric antrum and duodenum to record the antroduodenal MMC. The content of MOT in plasma was determined by radioimmunoassay. The expression of SP in gastric antrum and duodenum was investigated by immunohistochemical assay. Results: Compared with that in the model group, the period of MMC in the Qingzhishu group was shortened, the phase Ⅲ of MMC prolonged, with more frequency and higher amplitude, the percentage of antroduodenal coordinative contraction increased; the levels of plasma MOT in any other groups were higher, the expression levels of SP in the gastric antrum and duodenum in other groups were higher (P 0.01 , 0.05 ). Conclusion: The possible mechanism of functional dyspepsia is the abnormity of phase of MMC and the failure of antroduodenal coordinative contraction, which may be due to the changes of MOT and SP. Qingzhishu can regulate them to some extent to cure the FD with incoordination between the liver and stomach.