Effects of EGCG on Renal Oxidation in Streptozotocin-induced Diabetic Rats

Objective To investigate the influence of EGCG(epigallocatechin-3-gallate) on renal malondialdehyde (MDA),SOD,GSH-Px in the rat with type Ⅱ diabetics.Methods SD rats were divided into the control group,STZ-treated group,EGCG-treated group Ⅰand EGCG treated group Ⅱ.First,the rats in the latter three group were induced to be diabetic nephropathy by intraperitoneal injection with 65mg/kg streptozoticin(STZ),and then,EGCE was continuously given 2.5mg·kg~(-1)·d~(-1) and 5mg·kg~(-1)·d~(-1) 4 weeks after STZ injection in EGCG-treated group respectively.The MDA,SOD,GSH-Px in the rat were observed respectively.Results At 12 weeks diabetic rats vs control group:the renal index of kidney increased significantly,the antioxidation capability of kidney decreased significantly.No significant difference of blood glucose was found between diabetic rats EGCG treated,gruops.Comparing with diabetic group,the levels of blood lipid,serum creatinine,urinary albumin excretory rate,renal MDA,plansm Hcy in EGCG treatd groups decreased significantly,but the renal SOD and GSH-Px increased markedly.Conclusion EGCG is effectively in improving the biahemical parameters and renal pathologic change.EGCG possesses antioxidant properities that can increase the antioxidant capability of kidney,decrease oxidative stress.