Some Hot Issues in the Study of Gastroesophageal Reflux Disease

Gastroesophageal reflux disease (GERD) is a commonly seen gastrointestinal disorder. It has been extensively studied and steady improvements have been made continuously, such as the Los Angeles classification of esophagitis at endoscopy, the Montreal definition and classification of GERD, and the Prague C M criteria of Barrett's esophagus. Recognition of this disease gradually deepens, but many questions remain to be answered, including the diagnosis of endoscopic minimal change esophagitis, clinical differentiation of non-erosive reflux disease (NERD) and functional heartburn, detection and significance of non-acid reflux, and diagnosis and treatment of Barrett’s esophagus, etc.