Effects of Quercetin on monocrotaline-inducedpulmonary arterial hypertension in rats

Objective:To observe the treatment of Quercetin on pulmonary hypertension induced by monocrotaline(MCT) in rats. Method:Thirty male SD rats were randomly divided into 3 groups with 10 rats in each group: MCT group,treatment group and control group.The rats in MCT group and treatment group were given a single subcutaneously injection of MCT and control group were injected with normal saline.The rats were raised 21 days after injection,then Quercetins(100 mg·kg-1·d-1) were given orally for 20 days to treatment group and normal saline to control and MCT group.Then the mean pulmonary arterial pressure(mPAP) and right ventricular hypertrophy index(RVHI) were measured.The index of wall thickness of pulmonary arteriole was measured by acomputerized image analyzer.The expression of PCNA in pulmonary arterial was observed by immunohistochemistry. Result:mPAP,RVHI,WT%,WA% and PCNA were increased significantly in MCT group than those in control group and treatment group. Conclusion:Quercetin could reduce the expression of PCNA in pulmonary arterial by MCT,prevent MCT-induced inflammatory response,pulmonary vascular remodeling and the development of pulmonary hypertension.