Changes of MCV and MCH in pregnancy cycle and their values in screening of thalassemia

Objective:To explore the change regularity of mean corpuscular volume(MCV) and mean corpuscular hemoglobin(MCH) in pregnancy cycle and their values in screening of thalassemia.Methods:The data of blood analysis from 550 normal women of childbearing age in the hospital in 2007 were collected,110 cases were selected by random number table as control group,the mean value was calculated;4 958 pregnant women were selected as experimental group,the mean value was calculated.Corresponding curves were drawn according to the mean values in the two groups by SPSS12.0 software;the change regularity of MCV and MCH in different gestational weeks were observed and compared between the two groups;the data of blood analysis from 327 cases with thalassemia diagnosed by gene analysis were collected,the values of MCV and MCH in screening of thalassemia were analyzed by receiver operating characteristics curve(ROC).Results:The mean values of MCV and MCH were 86.7 fl and 29.8 pg in control group;in experimental group,the mean values of MCV and MCH increased with gestational weeks,peaked on 22~25 gestational weeks,then decreased;the area of MCV under ROC curve was 0.910,the area of MCH under ROC curve was 0.907;there was significant difference in MCV value on 26~29 gestational weeks between control group and experimental group;there was significant difference in MCH value on 22~29 gestational weeks between control group and experimental group;the mean values of MCV and MCH decreased from the 26th gestational week in experimental group.Conclusion:The mean values of MCV and MCH in pregnant women increase first and decrease afterwards with gestational weeks;MCV and MCH may screen out thalassemia carriers effectively during pregnancy.