Mechanism of Huoxue Zhitong Capsule in Treating Local Swelling and Pain

Objective:To investigate the influence of Huoxue Zhitong Capsule(HZC) in hemorheology and partial pressure of oxygen in patients with fracture combined with acute soft tissue injury(STI),and the mechanism involved.Methods:One hundred and twelve in-patients with fracture combined with STI from May 2009 to May 2010 were randomly assigned to treatment group(n=70) and control group(n=42).HZC and placebo were respectively given to patients in the two groups,2 capsules once,and three times each day.The changes in clinical symptoms and indexes including hemorrheology and partial pressure of oxygen were observed.Results:The patients' symptoms in treatment group were significantly improved,with soft tissue swelling and pain obviously ameliorated(P0.01).There were significant differences in indexes relating to hemorrheology in treatment group,such as blood viscosity,plasma viscosity,red cell aggregation index and rigid index,erythrocyte sedimentation rate equation quotient(K),fibrinogen(P0.05).No remarkable difference was found in control group in the above indexes(P0.05).After the treatment,significant difference was observed in partial pressure of oxygen in treatment group compared with before the treatment(P0.01),while there was insignificant difference in control group(P0.05).Conclusion: HZC can improve regional microcirculation,increase local oxygen supply and improve tissue metabolism,thus applying the function of detumescence and relieving pain.