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2008•Prevention and Treatment of Cardio-Cerebral-Vascular DiseaseRequires access

The Association between ABCA1 Gene R219K Polymorphism and Coronary Heart Disease

Zhang Huai

Open publisher page 8 citations

Abstract

Objective To explore the association between ATP binding cassette transporter 1(ABCA1) gene R219K polymorphism and coronary heart disease(CHD) in Chinese Han Population.Methods Using polymerase chain reaction-restrictive fragment length polymorphism(PCR-RFLP),162 CHD patients and 186 controls were analyzed for the polymorphism,genotype and allele distribution of ABCA1 gene R219K.Results The distribution of ABCA1 genotype in both groups was in Hardy-Weinberg equilibrium.The frequency of RK and KK genotype in control group was significantly higher than that in CHD group(73.66% vs 56.17%,P0.05);similarly,the frequency of K allele in control group was significantly higher that in CHD group(48.66% vs 36.11%,P0.01).After adjusted for the influence of age,gender and other CHD risk factors by multiple Logistic regression analysis,those people who have at least one allele markedly decrease CHD risk(OR=0.38,95%CI=0.22-0.65).Conclusions ABCA1 gene R219K polymorphism is associated with CHD risk in Chinese Han population,K allele may serve as a genetic protective factor for coronary heart disease.

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What this paper is about

Objective To explore the association between ATP binding cassette transporter 1(ABCA1) gene R219K polymorphism and coronary heart disease(CHD) in Chinese Han Population.Methods Using polymerase chain reaction-restrictive fragment length polymorphism(PCR-RFLP),162 CHD patients and 186 controls were analyzed for the polymorphism,genotype and allele distribution of ABCA1 gene R219K.Results The distribution of ABCA1 genotype in both groups was in Hardy-Weinberg equilibrium.The frequency of RK and KK genotype in control group was significantly higher than that in CHD group(73.66% vs 56.17%,P0.05);similarly,the frequency of K allele in control group was significantly higher that in CHD group(48.66% vs 36.11%,P0.01).After adjusted for the influence of age,gender and other CHD risk factors by multiple Logistic regression analysis,those people who have at least one allele markedly decrease CHD risk(OR=0.38,95%CI=0.22-0.65).Conclusions ABCA1 gene R219K polymorphism is associated with CHD risk in Chinese Han population,K allele may serve as a genetic protective factor for coronary heart disease.

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Available abstract

Objective To explore the association between ATP binding cassette transporter 1(ABCA1) gene R219K polymorphism and coronary heart disease(CHD) in Chinese Han Population.Methods Using polymerase chain reaction-restrictive fragment length polymorphism(PCR-RFLP),162 CHD patients and 186 controls were analyzed for the polymorphism,genotype and allele distribution of ABCA1 gene R219K.Results The distribution of ABCA1 genotype in both groups was in Hardy-Weinberg equilibrium.The frequency of RK and KK genotype in control group was significantly higher than that in CHD group(73.66% vs 56.17%,P0.05);similarly,the frequency of K allele in control group was significantly higher that in CHD group(48.66% vs 36.11%,P0.01).After adjusted for the influence of age,gender and other CHD risk factors by multiple Logistic regression analysis,those people who have at least one allele markedly decrease CHD risk(OR=0.38,95%CI=0.22-0.65).Conclusions ABCA1 gene R219K polymorphism is associated with CHD risk in Chinese Han population,K allele may serve as a genetic protective factor for coronary heart disease.

Key concepts: Genotype, ABCA1, Allele, Allele frequency, Genetics, Restriction fragment length polymorphism, Population, Gene polymorphism

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