ScholarLens Back to search
2004•Unpublished venueRequires access

Effects of salivae miltiorrhizae on apoptosis of hepatic cells in ischemia - reperfusion injury in rats

Li Su

Open publisher page 0 citations

Abstract

Objective:To study the effects of salivae miltiorrhizae(SM) on apoptosis of hepatic cells in ischemia - reperfusion(IR) injury in rats. Methods: The apoptosis of hepatic cells of rats with ischemia - reperfusion injury was observed by terminal deoxynuleotidy transferase - mediated nicked labeling(TUNEL) and the expression of apoptosis relative genes was determined by immunohistochemical staining. Then the effects of SM injection on apoptosis of hepatic cells of the animals were investigated. Results: After the ischemia - reperfusion injury, the typical apoptotic morphological characters in hepatic cells of these rats were observed, and there was very significantly difference of the rate of apoptotic liver cells between the IR group and SM group(p0.01). The expression of bcl - 2 decreased significantly in IR group, but increased in SM group(p0.01). Conclusion: SM may inhibit the apoptosis of hepatic cells induced by ischemia - reperfusion injury in rats.

About this research paper

What this paper is about

Objective:To study the effects of salivae miltiorrhizae(SM) on apoptosis of hepatic cells in ischemia - reperfusion(IR) injury in rats. Methods: The apoptosis of hepatic cells of rats with ischemia - reperfusion injury was observed by terminal deoxynuleotidy transferase - mediated nicked labeling(TUNEL) and the expression of apoptosis relative genes was determined by immunohistochemical staining. Then the effects of SM injection on apoptosis of hepatic cells of the animals were investigated. Results: After the ischemia - reperfusion injury, the typical apoptotic morphological characters in hepatic cells of these rats were observed, and there was very significantly difference of the rate of apoptotic liver cells between the IR group and SM group(p0.01). The expression of bcl - 2 decreased significantly in IR group, but increased in SM group(p0.01). Conclusion: SM may inhibit the apoptosis of hepatic cells induced by ischemia - reperfusion injury in rats.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective:To study the effects of salivae miltiorrhizae(SM) on apoptosis of hepatic cells in ischemia - reperfusion(IR) injury in rats. Methods: The apoptosis of hepatic cells of rats with ischemia - reperfusion injury was observed by terminal deoxynuleotidy transferase - mediated nicked labeling(TUNEL) and the expression of apoptosis relative genes was determined by immunohistochemical staining. Then the effects of SM injection on apoptosis of hepatic cells of the animals were investigated. Results: After the ischemia - reperfusion injury, the typical apoptotic morphological characters in hepatic cells of these rats were observed, and there was very significantly difference of the rate of apoptotic liver cells between the IR group and SM group(p0.01). The expression of bcl - 2 decreased significantly in IR group, but increased in SM group(p0.01). Conclusion: SM may inhibit the apoptosis of hepatic cells induced by ischemia - reperfusion injury in rats.

Key concepts: TUNEL assay, Apoptosis, Ischemia, Reperfusion injury, Immunohistochemistry, Endocrinology, Medicine, Chemistry

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Effects of salivae miltiorrhizae on apoptosis of hepatic cells in ischemia - reperfusion injury in rats — Research Paper | ScholarLens