2005•Pharmaceutical biotechnologyRequires access

Advances in Monoclonal Antibody Targeting Drugs of the Antitumor Antibiotics of Enediyne

WU Wu-tong

Abstract

Monoclonal antibody (McAb) was highly specific- to its antigen. Therefore, it was very attractive to explore the possible use of McAb and its conjugate for cancer treatment. The antitumor antibiotics of enediyne including neocarzinostatin, lidamycin. calicheamicins and their monoclonal antibody immunoconjugate were specifically summarized.

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Available abstract

Key concepts: Neocarzinostatin, Enediyne, Immunoconjugate, Monoclonal antibody, Calicheamicin, Conjugate, Antibiotics, Antibody