Improvement Effect of Soy Isoflavones(SI) on Serum Hormone Disorders and Benign Prostatic Hyperplasia(BPH) Induced by Nonylphenol(NP) in Rat

Objective To study the effect of nonylphenol(NP) on rats' prostatic index,histopathologic changes and the levels of sexual hormones level in serum;at the same time,to investigate whether soybean isoflavones(SI) has protective effect for NP's.MethodsIn this study,we exposed fifty healthy Wistar rats to 25.0 mg/kg NP,25.0 mg/kg NP+50.0 mg/kg SI,25.0 mg/kg NP +100.0 mg/kg SI,100.0 mg/kg SI in vitro for 30 days,the control group exposed to olive.After the treatment,the prostate wet weight,prostatic index and morphological changes and the serum hormones were observed.ResultsThe anterior lobe wet weight of prostate and organ coefficient in rats in group 25.0 mg/kg NP were significantly higher than those in olive group;and the anterior lobe wet weight and prostatic index in 25.0 mg/kg NP+50.0 mg/kg,25.0 mg/kg NP +100.0 mg/kg SI were significantly lower than those in 25.0 mg/kg NP group(P0.05);The serum E2 levels in each treatment group were lower than those in the olive group(P0.05 or P0.01);the serum testosterone(T) and E2/T in all exposed groups(except group 100 mg/kg SI)were significantly higher or lower respectively than that in the olive group(P0.05 or P0.01);the level of E2 and E2/T ingroup 25.0 mg/kg NP+50.0 mg/kg and 25.0 mg/kg NP +100.0mg/kg SI were significantly higher than those in the group of 25.0 mg/kg NP(P0.05);In NP group,we saw Prostatic hyperoplasia,although the glandular epithelial were rule and cavity acid secretion was less in of NP+SI group compared with 25.0 mg/kg NP group.ConclusionsThese results suggest Soybean isoflavones have significant antagonism effect on prostatic hyperplasia which caused by nonylphenol through regulated sex hormone levels in rats.