2001•Chinese New Drugs JournalRequires access

Efficacy of botulinum toxin A in the treatment of hemifacial spasm and blepharospasm

Hong Li

Abstract

Objective:To investigate the efficacy of botulinum toxin A in the treatment of hemifacial spasm and blepharospasm.Methods:Patients with hemifacial spasm( n =168) and blepharospasm ( n =12) were treated with botulinum toxin A given by local injection on multiple sites and the efficacy was observed.Results:A complete relief rate of 67.6%,an obvious relief rate of 22.6%,and a partial relief rate of 9.4% were obtained in all patients with a total effective rate of 100%.The onset of action of the drug was 1～7 day and lasted for (14.6±4.7) weeks for hemifacial spasm and (13.4±5.4) weeks for blepharospasm with mild and transient side effects.Conclusion:Botulinum toxin A given by local injection on multiple sites is effective in treatment of hemifacial spasm and blepharospasm. [

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Key concepts: Blepharospasm, Hemifacial spasm, Botulinum toxin, Medicine, Anesthesia, Surgery, Facial nerve