Clinical observation of varenicline for smoking cessation

Objective To observed the relationship between times and effects of treatment with varenicline for smoking cessation. Methods Twenty-five smokers who wish smoking cessation were observed. They were treated by varenicline, and the telephone follow-up were performed at weeks 2,4,6,8 and 12 after treatment, and the times of treatments and abstinence were recorded and analysis. Results The numbers of continuous abstinence participants were 12 from 9 to 12 weeks, and continuous abstinence rates were 48% ( 12/25 ) . The number of discontinuing abstinence participants were 13, and discontinuation rates were 52% (13/25). The average duration of treatment with varenicline was 7. 23 weeks in continuous abstinence participants, and it was longer than that in discontinuing abstinence participants (P =0.011). The continuous abstinence rates in longer-times of treatment (8～12 weeks) was higher than that in shorter-times of treatment ( P - 0. 027). Conclusion Varenicline was an efficacious pharmacotherapy for smoking cessation. The effect of treatment was related to times of treatment with varenicline.