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2010•Military Medical Journal of Southeast ChinaRequires access

Expression and significance of MMP-7,MMP-9,VEGF-C,and VEGF-D in gastric carcinomas

Zhou Zhi

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Abstract

Objective To investigate the expression and significance of MMP-7,MMP-9,VEGF-C,and VEGF-D in gastric carcinoma.Methods Immunohistochemical staining was employed to detect the expression of MMP-7,MMP-9,VEGF-C,and VEGF-D in 133 cases of gastric carcinoma.Results Expression of MMP-7 and MMP-9 were correlated with tumor invasion,lymph node metastasis,TNM staging and tumor differentiation(P0.05),and were not associated with tumor size and patient gender(P0.05).Expression of VEGF-C and VEGF-D was related to tumor invasion and lymph node metastasis(P0.05),while the significant correlation between VEGF expression and tumor size and patient gender was not observed(P0.05).Conclusion Expression of MMP-7,MMP-9,VEGF-C,and VEGFD was tightly associated with biological behavior of gastric carcinoma,which may be an available index for predicting tumor progression and prognosis.

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What this paper is about

Objective To investigate the expression and significance of MMP-7,MMP-9,VEGF-C,and VEGF-D in gastric carcinoma.Methods Immunohistochemical staining was employed to detect the expression of MMP-7,MMP-9,VEGF-C,and VEGF-D in 133 cases of gastric carcinoma.Results Expression of MMP-7 and MMP-9 were correlated with tumor invasion,lymph node metastasis,TNM staging and tumor differentiation(P0.05),and were not associated with tumor size and patient gender(P0.05).Expression of VEGF-C and VEGF-D was related to tumor invasion and lymph node metastasis(P0.05),while the significant correlation between VEGF expression and tumor size and patient gender was not observed(P0.05).Conclusion Expression of MMP-7,MMP-9,VEGF-C,and VEGFD was tightly associated with biological behavior of gastric carcinoma,which may be an available index for predicting tumor progression and prognosis.

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Available abstract

Objective To investigate the expression and significance of MMP-7,MMP-9,VEGF-C,and VEGF-D in gastric carcinoma.Methods Immunohistochemical staining was employed to detect the expression of MMP-7,MMP-9,VEGF-C,and VEGF-D in 133 cases of gastric carcinoma.Results Expression of MMP-7 and MMP-9 were correlated with tumor invasion,lymph node metastasis,TNM staging and tumor differentiation(P0.05),and were not associated with tumor size and patient gender(P0.05).Expression of VEGF-C and VEGF-D was related to tumor invasion and lymph node metastasis(P0.05),while the significant correlation between VEGF expression and tumor size and patient gender was not observed(P0.05).Conclusion Expression of MMP-7,MMP-9,VEGF-C,and VEGFD was tightly associated with biological behavior of gastric carcinoma,which may be an available index for predicting tumor progression and prognosis.

Key concepts: Medicine, Matrix metalloproteinase, VEGF receptors, Immunohistochemistry, Gastric carcinoma, Lymph node metastasis, Metastasis, Pathology

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Expression and significance of MMP-7,MMP-9,VEGF-C,and VEGF-D in gastric carcinomas — Research Paper | ScholarLens