2014•Unpublished venueRequires access
Effect of Xian Ling compound on estrogen level,bone mineral density and bone morphology in ovariectomized rats
Wang Li
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Abstract
Objectives: To study the effects of XianLing FuFang Preparation on osteoporosis in ovariectomized rats. Methods: The female 6-month-old SD rats were divided into sham operated group,ovariectomized group,high concentration XianLing FuFang Preparation with ovariectomized group, medium concentration XianLing FuFang Preparation with ovariectomized group and low concentration XianLing FuFang Preparation with ovariectomized group. Some biochemical indexes were examined after three months of administration. Bone mineral density( BMD) of lumbar vertebra bone of rats was determined by Dual Energy X-ray Absorptiometry( DEXA). Biomechanical characteristics of femur were measured by three point bending test. some tissue from the right thighbone were undertaken morphologic observation. Results: The levels of calcium and phosphorus in serum were significantly higher in the rats treated by different dosages of XianLing FuFang Preparation as compared with that in the osteoporosis control group. As for the level of E2,Ca2 +,P,SOD and MDA in serum,the difference was significant( P 0. 05) between the treated group and the control group. The resistance of bending and compression of femur of rats was enhanced,and the bone trabecula numbers and continuity of XianLing FuFang Preparation groups are obviously better than the other group. Conclusion: XianLing FuFang Preparation had antiosteoporotic effects on ovariectomized rats,and it was worth promoting.