Effect of Supplement of Soya Lecithine on Mucosal Anti-Oxidation and Heat Shock Protein 70 Content in Intrauterine Growth Retardation Piglets

【Objective】The effects of supplement of soya lecithine(SL) on intestinal growth,mucosal heat shock protein 70(HSP70) expression and oxidation stress(OS) in intrauterine growth retardation(IUGR) piglets were studied.【Method】Twelve IUGR piglets and six piglets with normal birth weight were selected.All piglets were weaned on 7th d of age,and assigned equally to three groups: six NBW and six IUGR piglets were fed with control diet(IUGR),and six IUGR piglets were fed with diet supplemented with 1.5% SL(IUGR+SL) for 7 days.【Result】IUGR decreased(P0.05) the absolute weigh of jejunal segment and non-mucosa,reduced(P0.05) the mucosal capacity of total anti-oxidation(T-AOC),as well as the activity of GR and GPx,and elevated(P0.05) the content of MDA.The mucosal HSP70 contents detected by ELISA and Western Blot were increased(P0.05) by IUGR.After SL treatment,the absolute and relative weight of jejunum,jejunal mucosa and non-mucosa increased(P0.05) in IUGR piglets.Supplement of SL increased(P0.05) the mucosal T-AOC,GPx and SOD,as well as reduced(P0.05) MDA and HSP70 content in terms of ELISA.Inverse correlations were found between SL supplementation in IUGR piglets and HSP70 contents(P0.05).【Conclusion】SL plays an important role in recovering impaired jejunal growth,increased mucosal HSP70,and OS induced by IUGR.