Surveillance of bacterial resistance from Sichuan cancer hospital in 2011

Objective To investigate the resistance of clinical isolates from Sichuan cancer hospital in 2011.Methods Antimicrobial susceptibility testing of 1 582 clinical isolates were carried out by means of MIC and results were analysed according to CLSI(2009).Results Of 1 582 clinical isolates,gram positive cocci and negative bacilli accounted for 10.1% and 89.9% respectively.Methicillin resistant strains in S.aureus(MRSA) accounted for 26.1%.The resistance rates of MRSA to β-lactams and other antimicrobial agents were much higher than those of methicillin-sensitive strains.No vancomycin or linezolid resistant strains were found.In Enter-ococcus spp,the resistance rates of E.faecium strains to most tested drugs were higher than those of E.faecalis.There was a strain resistant to vancomycin in E.faecium.No linezolid resistant strains were found.In enterobacteriaceae,ESBLs-producing strains accounted for 66.5% and 21.2% in E.coil and Klebsiella spp.respectively.ESBLs-producing strains were resistant to most β-lactams and some other antimicrobial agents.Imipenem was the most potent antimicrobial agent.Many multi-drug resistant strains in A.baumannii were found.Conclusion Bacterial resistance is still increasing in the hospital,especially VRE and multi-drug resistant A.baumannii strains.It is mandatory for the hospital to take effective control measures.