2005•Chinese Journal of New Drugs and Clinical RemediesRequires access
Effect of recombinant human growth hormone therapy in prepubertal children with idiopathic short stature
Shan Li
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Abstract
AIM: To observe the effect of recombinant human growth hormone (rhGH) in treating pre pubertal children with idiopathic short stature (ISS). METHODS: Twenty-four ISS children were divided into two groups. Twelve children in trea ting group (M 2, F 10; initial age of treatment (10.1±(s1.9))a ) undertak en with rh GH 0.10-0.13 (U·kg~(-1)·)d~(-1) for an average treating time of (0.8 ±0. 3) were comp ared with 12 children (M 2, F 10; initial age of observation (9.9±1.7)a ) of th e control group without given rhGH with the average observing time of ((1.1)±0. 5)a. RESULTS: After treatment, the growth velocity (GV) was (8.7±1.9) cm·a~(-1) in treati ng group and (5.0±0.7) cm·a~(-1) in control group. The height standard dev iation score of bone age (HtSDS_(BA)) increased 0.4±0.4 and predicted adult height (PHt) increased (3.1±0.9)cm in treating group. The HtSDS_(BA) decreas ed 0.3±0.5 and PHt decreased (0.9±1.7) cm in control group. There were signifi c ant difference between the two groups (P(0.01)). CONCLUSION: The rhGH can stimulate the growth of prepubertal children with ISS simultaneous ly increase with PHt.