2014•Zhonghua zhongyiyao xuekanRequires access
Effects of Eye-Acupuncture on Expressions of 5-HT in Hippocampus and Hypothalamus in Rats with Depression
L Wang
Open publisher page 0 citations
Abstract
Objective: To investigate the expressions of 5- hydroxytryptamine( 5- HT) in hippocampus and hypothalamus,and the effect of eye acupuncture intervention in a rat model of depression. Methods: Male rats of Wistar were allocated to normal,model of depression and eye acupuncture groups. An animal model of depression was made by chronic stress stimulation. Eye acupuncture intervention was given. 5- HT levels in serum,hippocampus and hypothalamus were measured by ELISA in each group. The expressions of 5- HT was measured by method of immunohistochemisty. Results: Compared with the normal group,in the group of depression model,5- HT levels in hippocampus were decreased obviously( P 0. 01),and 5- HT levels in serum increased obviously( P 0. 01). Compared with the group of depression model,in the group of eye acupuncture,5- HT levels in hippocampus and hypothalamus were increased obviously( P 0. 01). 5- HT levels in serum were decreased obviously( P 0. 01). Conclusion: Eye acupuncture can regulate the expressions of 5- HT in hippocampus and hypothalamus in a rat model of depression.