Studies on the serum SARS-CoV(IgG)antibody level in 2132 cases of different population

Objective:to evaluate the clinical significance of the measurement of serum SARS-CoV(IgG)antibody.Methods:The serum SARS-CoV antibody have been measured in different population by both ELISA method and biochips technique, to analyze the difference between SARS and other diseaseas. Results:The positive rate of SARS-CoV(IgG)in convalescent SARS cases, nephropathy, cancer, pulmonary diseases,diabetes and other diseases were 75.6%(118/156)、29.3%(22/75)、22.3%(19/85)、22.7%(10/44)、13.6%(8/59) respectively, both 500 healthy population and 500 close contact medical staff in xiao tang shan hospital were negative ,which were measured by ELISA method. The biochips results indicated that convalescentSARS cases have a positive rate of 86% and only 4 cases have positive SARS-CoV antibody in 62 cases which have positive results by ELISA.Conclusion:Measurement of SARS-CoV antibody is a helpful marker to diagnosis recent SARS-associated coronavirus (SARS-CoV) infection. Biochips technique has better specificity and sensitivity than ELISA.