Efficacy of Sufentanil Combined with Remifentanil in Awake Intubation with Anticipated Difficult Air Ways

Objective:To investigate the safety and effectivity of sufentanil combinde with remifentail in awake intubation with difficult air ways.Methods:Atotal of 66 patients with known difficult airways who underwent awake tracheal intubation were recruited.Patients were randomly divided into three groups(namely Group Ⅰ,Group Ⅱ and Group Ⅲ).After sufficient superficial anesthesia,group Ⅰ(n=22)received thyrocricoid puncture,and then injected 2ml(2%) lidocaine before intubating;Group Ⅱ(n=22) received remifentanil 0.75 μg/kg in bolus,followed by acontinuous infusion of 0.075 μg·kg-1·min-1,and group Ⅲ(n=22) receivde sufentanil 0.75μg/kg in bonus,followed by continous infusion of remifentanil 0.075 μg·kg-1·min-1.The outcomes included HR,BP and SpO2 before,during and after intubation.Results:All the patients wer able to complete awake intubation.Haemodynamic changes in group Ⅲ were significantly fewer than in group Ⅰ and group Ⅱ.We found significant differences among the three groups.Conclusion:After superficial anaesthesia,awake intubation is better achinved by continous injection of sufentanil combined with remifentanil,which fewer haemodynamic changes,and more comfort and safety.