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2006•Zhongguo jiceng yiyaoRequires access

Changes of serum level of IL-18 and IL-15 In patients with acute pancreatitis

Pan Li-l

Open publisher page 1 citations

Abstract

Objective To investigate the role of interleukin-18(IL-18) and interleukin-15(IL-15) in the mechanism of acute pancreatitis.Methods The serum levels of IL-18 and IL-15 were detected by enzyme-linked immunosorbent assay(ELISA) in SAP group(n=7) and MAP group(n=19).The relationship between IL-18 and IL-15 were analyzed.Results SAP group was compared with the MAP group:IL-18 (78.32±15.45)ng/L vs (28.21±13.18)ng/L,P0.01 and IL-15 (42.17±19.15)ng/L vs (5.88±2.01)ng/L,P0.01,in SAP group was higher than that in MAP group obviously;There was significant positive correlation between IL-15 and IL-18 in both MAP group(r=0.95,P0.01) and in SAP group(r=0.91,P0.01).Conclusion IL-18 and IL-15 play important roles in the development of acute pancreatitis,they may be valuable indexes to predict the severity of AP.

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What this paper is about

Objective To investigate the role of interleukin-18(IL-18) and interleukin-15(IL-15) in the mechanism of acute pancreatitis.Methods The serum levels of IL-18 and IL-15 were detected by enzyme-linked immunosorbent assay(ELISA) in SAP group(n=7) and MAP group(n=19).The relationship between IL-18 and IL-15 were analyzed.Results SAP group was compared with the MAP group:IL-18 (78.32±15.45)ng/L vs (28.21±13.18)ng/L,P0.01 and IL-15 (42.17±19.15)ng/L vs (5.88±2.01)ng/L,P0.01,in SAP group was higher than that in MAP group obviously;There was significant positive correlation between IL-15 and IL-18 in both MAP group(r=0.95,P0.01) and in SAP group(r=0.91,P0.01).Conclusion IL-18 and IL-15 play important roles in the development of acute pancreatitis,they may be valuable indexes to predict the severity of AP.

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Available abstract

Objective To investigate the role of interleukin-18(IL-18) and interleukin-15(IL-15) in the mechanism of acute pancreatitis.Methods The serum levels of IL-18 and IL-15 were detected by enzyme-linked immunosorbent assay(ELISA) in SAP group(n=7) and MAP group(n=19).The relationship between IL-18 and IL-15 were analyzed.Results SAP group was compared with the MAP group:IL-18 (78.32±15.45)ng/L vs (28.21±13.18)ng/L,P0.01 and IL-15 (42.17±19.15)ng/L vs (5.88±2.01)ng/L,P0.01,in SAP group was higher than that in MAP group obviously;There was significant positive correlation between IL-15 and IL-18 in both MAP group(r=0.95,P0.01) and in SAP group(r=0.91,P0.01).Conclusion IL-18 and IL-15 play important roles in the development of acute pancreatitis,they may be valuable indexes to predict the severity of AP.

Key concepts: Medicine, Acute pancreatitis, Pancreatitis, Internal medicine, Gastroenterology, Interleukin 1β, Interleukin, Positive correlation

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