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2000•Journal of Jiangsu Clinical MedicineRequires access

HUMAN SRY GENE EXPRESSION AND CLINICAL SIGNIFICANCE IN THE PATIENTS WITH SEXUAL DIFFERENTIATION

GU Hui-xin

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Abstract

Objective: To investigate the effect of sex-determining region of the Y chromosome (SRY) on sexual differentiation. Methods: The SRY genes of 8 patients with sexual differentiation were detected by polymerase chain reaction and the chromosome karyotypes were analyzed. Results: The SRY genes were positive in four female cases with 46, XY. The SRY was positive in one out of four male cases with 46, XX male while the rest were negative. Conclusions: Detection of the SRY gene plays an important role in sexual abnormal development diagnosis.

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What this paper is about

Objective: To investigate the effect of sex-determining region of the Y chromosome (SRY) on sexual differentiation. Methods: The SRY genes of 8 patients with sexual differentiation were detected by polymerase chain reaction and the chromosome karyotypes were analyzed. Results: The SRY genes were positive in four female cases with 46, XY. The SRY was positive in one out of four male cases with 46, XX male while the rest were negative. Conclusions: Detection of the SRY gene plays an important role in sexual abnormal development diagnosis.

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Available abstract

Objective: To investigate the effect of sex-determining region of the Y chromosome (SRY) on sexual differentiation. Methods: The SRY genes of 8 patients with sexual differentiation were detected by polymerase chain reaction and the chromosome karyotypes were analyzed. Results: The SRY genes were positive in four female cases with 46, XY. The SRY was positive in one out of four male cases with 46, XX male while the rest were negative. Conclusions: Detection of the SRY gene plays an important role in sexual abnormal development diagnosis.

Key concepts: Testis determining factor, Y chromosome, Karyotype, Sexual differentiation, Gene, Polymerase chain reaction, Chromosome, Medicine

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