Etiology and Antimicrobial Susceptiblity of Children with Bacterial Meningitis

Objective To review the etiology,antimicrobial susceptiblity in children with bacterial meningitis at children′s hospital of fudan university from 2000 to 2005.Methods The bacteria from cerebrospinal fluid(CSF) was evaluated by Grain stain,API system,ⅩorⅤ factor test,Optochin test.The antigen detection(latex agglutination test,LAT) was done for neisseria meningitidis,streptococcus pneumoniae and B haemophilus influenzae.The antimicrobial susceptibility was detected by KB and E-test.Results The predominant bacteria tested by LAT were streptococcus pneumoniae(20.0%),B haemophilus influenzae(15.4%),and neisseria meningitis((7.7%)).The predominant bacteria isolated from culture were staphylococcus epidermidis(15.4%),and 88.9% of them were(methicil)-linresistant staphylococcic(MRS).Conclusions The predominant bacteria in children with meningitis are streptococcus pneumoniae,B haemophilus influenzae and neisseria meningitidis.The isolating rate of strphylococcus is higher in recent years and most of them are MRS. The etiology of BM varies in different areas of China.