Contrast-induced nephropathy in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention

Objective To analyze the effect of contrast medium on renal function in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention (PCI),and to assess the clinical predictors and outcome of contrast-induced nephropathy (CIN). Methods In 118 patients with acute myocardial infarction who underwent primary PCI,serum creatinine (Scr) concentration was measured at baseline and on the 48th hour,72nd hour after PCI,and clinical events were observed during hospitalization. Results CIN occurred in 28 (23.7%) patients. The baseline glomerular filtration rate (GFR) was lower in CIN group than that in non-CIN group (P0.05). The left ventricular ejection fraction(LVEF) was lower and peak creatine kinase was higher in CIN group than that in non-CIN group(P0.05). The CIN group had longer hospital stay (P0.01) and more complicated clinical course than non-CIN group. Multivatiate analysis showed that LVEF40%,peak CK3 000 U/L were correlated with CIN. Conclusions Contrast-induced nephropathy frequently complicates primary percutaneous coronary intervention. It is associated with higher in-hospital complications. Thus,preventive strategies are needed.