Clinical comparison of sevoflurane-remifentanil and midazolam-remifentanil anesthesia in pediatric cleft lip and palate surgery

Objective To compare the clinical effects and safety of sevoflurane-remifentanil and midazolam-remifentanil anaesthesia for cleft lip and palate repair surgery in children.Methods Sixty children undergoing elective cleft lip and palate repair surgery were randomly divided into two groups,30 cases in each group.Group S: sevoflurane and remifentanil anaesthesia;Group M: midazolam,remifentanil and vecurinium anaesthesia.Heart(HR),mean arterial pressure(MAP) and pulse oxygen saturation(SpO2)were served,and recorded at the time before the induction(T1),intraoperative(T2) and postoperative(T3).The time to recovery,incidence of restlessness,postoperative nausea vomiting,and the complications of the airway were recorded.Results There was no significantly difference between the two groups with respect to sex,age,weight or the time of operation.T2 point of MAP,HR was significantly lower than T1,T3 point in time,children waking time,time away from the operating room and lethargy of group M were significantly higher than that of group S,while the incidence of agitation.Postoperative nausea and vomiting in group S was significantly higher than that in group M.Conclusion Both methods have their advantages,they can be used for this operation safely.