Clinical study of serum cystatin C and serum creatinine in early diagnosis and prognosis predictive value of acute kidney injury

Objective To assess the clinic value of serum cystatin C and serum creatinine in the prediction of acute kidney injury. Methods A total of 66 acute kidney injury patients were chosen as the observing group and another 66 healthy subjects as control group. The level of serum cystatin C and serum creatinine were detected. Results The level of serum cystatin C in patients with acute kidney injury was progressively increased since admission(P 0. 05),while the level of serum creatinine was progressively increased since 12h after admission(P 0. 05); The level of serum cystatin C and serum creatinine in acute kidney injury group were significantly higher than that in non-acute kidney injury group(P 0. 05),the diagnostic rate obtained by serum cystatin C index weresignificantly higher than that by the serum creatinine index(P 0. 05). Conclusion Compared to the conventional biomarkers,the earlier emergence of serum cystatin C can contribute better to early clinical diagnosis of acute kidney injury.