The Effects of Bcl2 Expression on the Clinicopathological Features and Prognosis of Diffuse Large B Cell Lymphoma from Different Cell Origins

Objective:To investigate the influence of Bcl2 expression on clinicopathological features and prognosis of diffuse large B cell lymphoma(DLBCL)developed from different cell origins.Methods:Tissues of 42 cases of DLBCL were screened from 180 cases of B cell non-Hodgkin lymphoma.Sections were stained with routine HE method,and immunophenotypes of neoplastic cell,such as CD20,CD3,CD10,Bcl6,Bcl2 and MUM1,were examined with immunohistochemistry(IHC)stained sections.The clinical and pathological data of all cases were collected.Some patients were followed up.Statistical analysis was done.Results:The expression of Bcl2 was found in 31 out of 42 case of DLBCL(73.8%).There was no statistically significant difference of Bcl2 expression between GBC-like(14/17)and ABC-like(17/25)DLBCL.The relation of Bcl2 expression with age,sex,site of DLBCL was not found,but it was associated with clinical staging of the disease.The stages of Bcl2-positive DLBCL cases were later than those of Bcl2-negative DLBCL cases(P0.05).Most of the DLBCL cases that originated outside nodes showed positive expression of Bcl2(5/6).There was a tendency that the survival status of Bcl2-positive cases was worse than that of Bcl2-negative cases(P=0.06).Conclusions:The expression of Bcl2 in DLBCL doesn't associate with the gene expression spectra obviously,but it affects the clinical course and prognosis of DLBCL.Bcl2 may be one of predictive factors for prognosis of DLBCL.