Clinical observations on effects of adenosini triphosphas on preventing cardiovascular response in extubation

Objective:To observe the effects of adenosini triphosphas(ATP) on prevention of cardiovascular response to endotracheal extubation when a patient came to his consciousness from general anesthesia. Methods: Forty patients(ASA Ⅰ to Ⅱ) undergone general anesthesia were randomly allocated to observation and control group with 20 in each. Observation group were given intravenous drip with adenosini triphosphas at a dose of 0.3 mg/kg 5 min prior to extubation, whereas control group received no medication. Systolic blood pressure(SBP), diastolic blood pressure(DBP), heart rate(HR) and mean arterial pressure(MAP) were recorded 5 min before extubation, during extubation, at 1 min, 3 min and 6 min after extubation, respectively, and RPP was determined. Results: All indexes were significantly decreased during extubation, at 1 min and 3 min after extubation compared with control group (p0.01 or 0.05). But the indexes between observation group and control group showed no striking difference at 5 min before extubation and 6 min following extubation. Conclusion: Administration of adenosini triphosphas at a dose of 0.3 mg/kg can prevent patients from cardiovascular response when patients are in condition of palinesthesia.