2007•Xumu yu shouyiRequires access

Apoptosis of chicken thymus lymphocytes induced by newcastle disease virus F48E8 in vivo

Lan Zhong-bao

Abstract

Light microscope,transmission electron microscope,electrophoretic analysis of DNA fragmentation and terminal deoxynucleotidyl transfers(TdT) dUTP nick and labeling(TUNEL) were used to study the apoptosis of chicken thymus lymphocytes induced by Newcastle Disease Virus(NDV) F48E8 in vivo. The results showed that chicken thymus lymphocytes exhibited obvious apoptosis.Moreover the apoptotic index of infected group was significantly higher than that of the control group(P0.01).It suggested that NDVF48E8 can induce apoptosis of chicken thymus lymphocytes in vivo,which will lead to immunodepression and may be the most important pathogeny.

About this research paper

What this paper is about

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: TUNEL assay, Apoptosis, In vivo, Terminal deoxynucleotidyl transferase, Newcastle disease, DNA fragmentation, In Situ Nick-End Labeling, Virus