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Expression of ERCC1 and the correlation with chemotherapy effect and prognosis in non-small cell lung cancer after surgery

Shan Li

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Abstract

Objective To study the expression of ERCC1 and the correlation with effect of platinum-based adjuvant chemotherapy as well as its impact on prognosis of non-small cell lung cancer(NSCLC) after surgery.Methods Expression of ERCC1 in 63 cases of NSCLC paraffin-embedded pathological specimens were determined by immunohistochemistry method.The association between the ERCC1 expression and response to chemotherapy as well as survival data were analyzed.Results Positive rate of ERCC1 expression in NSCLC was 26.9%.Expression of ERCC1 and pTNM stage were independent determinants to the prognosis of NSCLC after surgery.The survival time in ERCC1 negative group was longer than that in ERCC1 positive group.Patients with negative expression of ERCC1 in NSCLC showed a trend of improved survival time under platinum-based adjuvant chemotherapy.Conclusions ERCC1 can be used as a molecular marker of prognosis in NSCLC after surgery.

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Objective To study the expression of ERCC1 and the correlation with effect of platinum-based adjuvant chemotherapy as well as its impact on prognosis of non-small cell lung cancer(NSCLC) after surgery.Methods Expression of ERCC1 in 63 cases of NSCLC paraffin-embedded pathological specimens were determined by immunohistochemistry method.The association between the ERCC1 expression and response to chemotherapy as well as survival data were analyzed.Results Positive rate of ERCC1 expression in NSCLC was 26.9%.Expression of ERCC1 and pTNM stage were independent determinants to the prognosis of NSCLC after surgery.The survival time in ERCC1 negative group was longer than that in ERCC1 positive group.Patients with negative expression of ERCC1 in NSCLC showed a trend of improved survival time under platinum-based adjuvant chemotherapy.Conclusions ERCC1 can be used as a molecular marker of prognosis in NSCLC after surgery.

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Available abstract

Objective To study the expression of ERCC1 and the correlation with effect of platinum-based adjuvant chemotherapy as well as its impact on prognosis of non-small cell lung cancer(NSCLC) after surgery.Methods Expression of ERCC1 in 63 cases of NSCLC paraffin-embedded pathological specimens were determined by immunohistochemistry method.The association between the ERCC1 expression and response to chemotherapy as well as survival data were analyzed.Results Positive rate of ERCC1 expression in NSCLC was 26.9%.Expression of ERCC1 and pTNM stage were independent determinants to the prognosis of NSCLC after surgery.The survival time in ERCC1 negative group was longer than that in ERCC1 positive group.Patients with negative expression of ERCC1 in NSCLC showed a trend of improved survival time under platinum-based adjuvant chemotherapy.Conclusions ERCC1 can be used as a molecular marker of prognosis in NSCLC after surgery.

Key concepts: ERCC1, Lung cancer, Chemotherapy, Medicine, Oncology, Internal medicine, Adjuvant chemotherapy, Immunohistochemistry

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Expression of ERCC1 and the correlation with chemotherapy effect and prognosis in non-small cell lung cancer after surgery — Research Paper | ScholarLens