Antimicrobial resistance of ESBLs-producing Escherichia coli

Objective To investigate the antimicrobial resistance of extended-spectrum β-lactamases(ESBLs) of Escherichia coli (E.coli) isolated from the First People's Hospital of Kunming.Methods 293 strains of E.coli were isolated between January and December,2006,ESBLs of E.coli were confirmed by phenotype confirmatory test,antimicrobial susceptibility were detected by Kirby-Bauer method.Results 168 of 293 (57.34%) strains of E.coli were ESBLs-producing strains.The main specimens isolated ESBLs-producing strains was sputum (64.71 %),the next were blood (62.50%) and pus (57.14%) ; Among departments,intensive care unit had the highest isolation rate of ESBLs-producing E.coli(65.22%),the next were department of endocrinology(65.00%) and oncology(63.33% ).Except imipenem and amikacin,the resistant rates of ESBLs-producing strains against the other 14 antimicrobial agcnts were significantly higher than non ESBLs-producing strains (all P0).01 ); ESBLsproducing strains were resistant to penicillins,cephalosporins,aztreonam,quinolones,aminoglycosides and sulfonamides, the resistant rate to imipenem and amikacin was both 5%,which was 0.00% and 3.30% respectively. Conclusion The prevalence of ESBLs is high among clinical E.coli isolates in the First People's Hospital of Kunming; ESBLs-producing strains are highly resistant to multiple antimicrobial agents,clinicians should choose antimicrobial agents rationally.