Investigation of the Relationship between Pathologic Type,Clinical Indicators and the Glomerular Filtration Rate of Lupus Nephritis Patients

Objective:To explore the relationship between pathologic type of lupus nephritis(LN) and glomerular filtration rate(GFR),the relationship between pathologic type of LN and clinical indicators.Methods:Serum creatinine,blood urea nitrogen,plasma albumin,24 hours urine protein,C3,C4,anti-dsDNA antibody titer,body weight of 39 patients were measured who intended to have a renal biopsy in the coming week and their age and SLEDAI score were recorded and MDRD-7 equation was used to reckon the GFR.Results:There were no significant differences in serum creatinine,blood urea nitrogen and GFR in all pathological types(P 0.05) in the 39 patients with LN and there were significant differences in plasma albumin(P 0.05);Through correlation analysis,there were negative correlation between the 24 hours urine protein and GFR(r=-0.330,P=0.040),but no correlation with C3,C4,anti-dsDNA antibody titer and SLEDAI score.Conclusion:Pathological types of LN can't replace GFR on the evaluation of renal function;24 hours urine protein of the LN can,to some extent,evaluate the renal function;The level of SLEDAI score,C3,C4 and anti-dsDNA antibody can not reflect the degree of kidney damage.