Expression of Differentiation Antigen of Acute Myeloid Leukemia and it's Relationship with Clinical Characteristics and Prognosis

Objective To analyze expression of differentiation antigen of acute myeloid leukemia(AML) and its relationship with clinical characteristics and prognosis.MethodsThe expression of differentiation antigen of 111 cases of AML was investigated by flow cytometry assay.Results(1)The frequency of antigen expression on blast cells in AML were 89.2%(CD13),79.3%(CD33),50.5%(CD34),37.8%(CD15),36.9%(HLA-DR) and 21.6%(CD14) respectively.HLA-DR was negative in M3 patients.CD7,one of the lymphoid antigens,was found to be expressed frequently in the AML blast cells.(2)The expression of CD15+ of AML was related with the blasts' count and white blood cell count.Those patients with CD7+ usually had spleno-hepatomegaly.(3)The CR rate in the cases with CD34+ was significantly lower than those with CD34-,but the time to CR was longer.CR rate in CD7+ cases was significantly lower than those with CD7-.However,patients with CD19-had lower CR rate than those with CD19+.But interestingly,CR rate in cases with CD7+CD34+ was significantly lower than those with CD7-CD34-.ConclusionCD7,CD19 and CD34 are relating with the clinical characteristics and prognosis of AML,and could be the one of important factors in predicting prognosis.