Analysis on Curative Effect of Sequential Therapy in Treatment of Children with Helicobacter Pylori Infection

Objective To explore on curative effect of sequential therapy in treatment of children with Helicobacter pylori.Methods 200 children with Hp who fitted in radical indication were randomly divided into four groups(n=50) and were radically treated with different methods for 10 d.In sequential therapy group,the therapy method was Omeprazole+Amoxicillin for the first five days and Omeprazole+ Clarithromycin+Metronidazole for the last five days;while in PAC group,the treatment was Omeprazole+Amoxicillin+Clarithromycin for ten days;in PAM group,the treatment was Omeprazole+Amoxicillin+Metronidazole for ten days;in quadruple therapy group the method was Omeprazole+ colloid ranitidine bismuth citrate +Clarithromycin +Amoxicillin for ten days.The Hp eradication rates of the four groups were compared.Results The eradication rate of sequential therapy group,PAC group,PAM group and quadruple therapy group was 90%,72%,70% and 94% respectively,the differences in the 4 groups were statistically significant(P0.05),and the differences between sequential therapy group and PAC group or PAM group were also statistically significant(χ2=5.2632,χ2=6.25,with an average P0.05).But the difference between sequential therapy group and quadruple therapy group was not statistically significant(χ2=0.1359,P0.05);the differences between quadruple therapy group and the PAC group or PAM group were statistically significant(χ2=8.5755,χ2=9.7561,average P0.01);the difference between PAC group and PAM group was not statistically significant(χ2=0.0486,P0.05).The different incidence rates in the 4 groups were not statistically significant(P0.05).Conclusion The sequential therapy has a higher eradication rate of Helicobacter pylori with less adverse reaction.It may be a new first-line solution in treatment of children with Hp infection with good effect.