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Study on the Relation between the Expression of mRNA in Peripheral Blood from the Patients with NSCLC and the Prognosis of the Patients

Meng Guangwei

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Abstract

Objective: The aim was to explore the relation between the expression of mRNA(carcinoembryonic antigen mRNA: CEA mRNA and cytokeratin 19 mRNA: CK19 mRNA) in peripheral blood from the patients with non-small cell lung cancer(NSCLC) and the prognosis of the patients.Method: The peripheral blood samples were from 97 cases of NSCLC.CEA mRNA and CK19 mRNA in the blood were detected by reverse transcriptase-nested primers-polymerase chain reaction.The life cycle of 36 months were compared between the positive index of the mRNA and the negative in the blood of the patients.Result: The survival cases of NSCLC patients in the negative mRNA group especially into 24 months were much more than the positive mRNA group(P0.01-P0.05).Conclusion: The detection of CEA mRNA and CK19 mRNA in peripheral blood are useful index in the objective estimate of the prognosis of NSCLC patients.

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What this paper is about

Objective: The aim was to explore the relation between the expression of mRNA(carcinoembryonic antigen mRNA: CEA mRNA and cytokeratin 19 mRNA: CK19 mRNA) in peripheral blood from the patients with non-small cell lung cancer(NSCLC) and the prognosis of the patients.Method: The peripheral blood samples were from 97 cases of NSCLC.CEA mRNA and CK19 mRNA in the blood were detected by reverse transcriptase-nested primers-polymerase chain reaction.The life cycle of 36 months were compared between the positive index of the mRNA and the negative in the blood of the patients.Result: The survival cases of NSCLC patients in the negative mRNA group especially into 24 months were much more than the positive mRNA group(P0.01-P0.05).Conclusion: The detection of CEA mRNA and CK19 mRNA in peripheral blood are useful index in the objective estimate of the prognosis of NSCLC patients.

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Available abstract

Objective: The aim was to explore the relation between the expression of mRNA(carcinoembryonic antigen mRNA: CEA mRNA and cytokeratin 19 mRNA: CK19 mRNA) in peripheral blood from the patients with non-small cell lung cancer(NSCLC) and the prognosis of the patients.Method: The peripheral blood samples were from 97 cases of NSCLC.CEA mRNA and CK19 mRNA in the blood were detected by reverse transcriptase-nested primers-polymerase chain reaction.The life cycle of 36 months were compared between the positive index of the mRNA and the negative in the blood of the patients.Result: The survival cases of NSCLC patients in the negative mRNA group especially into 24 months were much more than the positive mRNA group(P0.01-P0.05).Conclusion: The detection of CEA mRNA and CK19 mRNA in peripheral blood are useful index in the objective estimate of the prognosis of NSCLC patients.

Key concepts: Medicine, Carcinoembryonic antigen, Messenger RNA, Cytokeratin, Peripheral blood, Reverse transcriptase, Lung cancer, Internal medicine

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Study on the Relation between the Expression of mRNA in Peripheral Blood from the Patients with NSCLC and the Prognosis of the Patients — Research Paper | ScholarLens