Effects of bFGF on the SOD Activity,MDA Content and Expressions of Bax and Bcl-2 Genes in Rat Hippocampus after Intracerebral Hemorrhage

Objective:To study the effects of basic fibroblast growth factor(bFGF)on the activity of SOD,MDA content and expressions of Bax and Bcl-2 genes in rat hippocampus with intracerebral hemorrhage(ICH).Methods: The experimental ICH rat models were established by injecting collaginase Ⅶ into the internal capsule and randomly divided into ICH,normal saline(NS) and bFGF treated groups.The activity of SOD and content of MDA in hippocampus were measured,and the expression levels of Bax and Bcl-2 genes in hippocampus were evaluated by RT-PCR.Results: After bFGF intervention,SOD activity in the hippocampus in the bFGF group was significantly increased when compared with the NS control group P0.05),whereas the MDA contents were significantly decreased(P0.05).The expression of Bax gene in the bFGF group was lower than that in the NS control group(P0.05),while the expression of Bcl-2 gene in the bFGF group was increased significantly(P0.05).Conclusion: bFGF could provide a neuroprotective effect by eliminating free radicals,improving SOD activity and suppressing neural apoptosis.