Clinical efficacy and safety of simple subglotfic secretion drainage and flushing on prevention of ventilator-associated pneumonia

OBJECTIVE To reduce the occurrence of lower respiratory tract infection(LRTI) associated with ventilator by adopting simple and effective methods.METHODS A11 patients supported by respiratory machine in ICU were divided into two groups ramdonly,one group treated with simple subglotfic secretion drainage and flushing ventilator associated pneumonia(VAP) while other group as control.The total number of cases were 320,which included 225 male and 95 female with the mean age 48±12.Periodically tests were done to two groups for their bacterial culture samples obtained from oropharynx,subglottic secretion and lower respiratory tract,also the time of occurrence of VAP and the case fatality rate were recorded.RESULTS Totally 34 cases occurred VAP in test group,which was significantly lower than that in control group(63 cases) Mortality of treated group(10.3%) was lower than that of control group(16.5%).MV time of treated group(9±14)d was shorter than that of control group(4.6±2.0)d,(P0.002).The onset of VAP was delayed in the treated group [VAP:(8.8±3.6)d]as compared with the control group [VAP:(4.6±2.0)d,P0.05].and statistic data was shown significantly.However,no significantly statistic differences were found in the lengths of hospital stay(28±25)d in treated group and control group(31±22)d,which shown P value for 0.563.CONCLUSION Simple subglottic secretion drainage and flushing can reduce the incidence of VAP and fatality rate,delay the onset of VAP and shorten MV time.