Curative effects of the FOLFOX_4 regimen in the treatment of adavanced gastric cancer

Objective:To observe the curative effects and adverse reactions of the FOLFOX_4 regimen(oxaliplatin combined with fluorouracil and calcium folinate) in the treatment of adavanced/metastatatic gastric cancer. Motheds:Total of 124 patients with advanced gastric cancer were treated by FOLFOX_4 regimen:oxaliplatin 150 mg/ m~2,ivgtt,d_1;calcium folinate 200 mg/m~2,ivgtt,2 hours,d_(1-2);followed by 5 - FU 400mg/m~2,iv,d_(1-2) and 600mg/ m~2,22 hours,civ,d_(1-2),two weeks were a cycle.Efficacy was evaluated after4 cycles.Results:In all 124 patients evaluated, total 546 cycles were given,average 4.4 cycles,complete response(CR) 12/124(9.7%),partial response (PR) 52/124(41.9%),stable disease(SD) 37/124(29.8%),progression disease(PD) 23/124(18.5%),overall response rate 64/124(51.6%).The major toxicity was neurotoxicity and hematotoxicity,less gastrointestinal side effects;Ⅲ-Ⅳadverse reactions included:neurotoxicity 62/124(50%),neutropenia 40/124(32.2%),thrombocytopenia 16/124(12.9%),nausea vomiting 37/124(29.8%).Conclusion:The regimen of FOLFOX_4 is effective and tolerable in advanced gastric cancer.