2006•Zhongguo xiandai yixue/Zhongguo xiandai yixue zazhiRequires access
Ischemia preconditioning and medicine preconditioning protects against ischemia-reperfusion injury of rats liver
Rui-xiang Mo
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Abstract
【Objective】 To investigate the protective mechanism of dipyridamole preconditioning and ischemia preconditioning against hepatic ischemia reperfusion injury.【Methods】 Using ischemia-reperfusion rat model in normal temperature,ischemia preconditioning and medicine preconditioning before ischemia.The content of adenosine phosphates in liver was examined.An hour later blood was taken from portal vein to examine the enzyme levels,including ALT,LDH and TNF-α,ET-1.The alteration of pathological morphology of the ischemia lobe was observed.The content of myeloperoxidase(MPO) in liver was examined.【Results】 A significant increase in adenosine was found immediately after the hepatic IPC,DPC as compared with the control group(P 0.01).The two enzemes,TNF-α,ET-1 levels of ischemia-reperfusion group were significantly higher than those of the control group(P 0.01).The indices of the dipyridamole group were much lower than those of the ischemia-reperfusion group(P 0.01),but little higher than those of the control group(P 0.05).The control group had obvious alteration in pathological morphology,but only slight alteration in IPC,DPC group,compared with the control group.【Conclusion】 Dipyridamole preconditioning and ischemia preconditioning protect against ischemia-reperfusion injury of the liver.Adenosine may play an critical role for the protection.Dipyridamole preconditioning might imitate the effect of IPC.