2011•Zhongguo shiyan fangjixue zazhiRequires access
The effects of Cuyu Granule on Nitric Oxide,Gastrin in Serum and Plasma Neurotensin in Rats with Gastric Ulcer Induced by Acetic Acid
Haijun Wen
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Abstract
Objective:To investigate the effect of Cuyu granule on the nitric oxide(NO),gastrin(GAS) in serum and neurotensin(NT) in blood plasma in rats with gastric ulcer induced by acetic acid.Method: The rats were randomly divided into four groups:control group,model group,Cuyu granule(28.8 g·kg-1)group and Ranitidine(27 mg·kg-1)group.The rat model of gastric ulcer was induced by acetic acid.The pH meter was used to measure the pH of stomach liquid.The content of gastrin in serum and NT in blood plasma were detected with radio immunoassay.The level of NO in serum was determined by the method of nitric acid reductase.Result: Compared with model group,the pH of stomach liquid,the contents of gastrin and NO in Cuyu granule group were increased as NT in blood plasma decreased significantly(P0.05).Compared with ranitidine group,the pH of stomach liquid,the content of gastrin in serum and NT in blood plasma of Cuyu granule group showed no differences,but the level of NO in serum was increased significantly(P0.05).Conclusion: Cuyu granule can ameliorate the quality of reborn mucosa and increase pHin treatment of gastric ulcer.The mechanism may be related to regulation of NO,Gas and NT.