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2010•Unpublished venueRequires access

Pharmacokinetics of Curcumin Microcystin in Rats

DU Tie-liang

Open publisher page 2 citations

Abstract

Objective:To study the pharmacokinetics of curcumin microcystin in rats.Methods: The microcystin was orally administrated.After carotid artery cannulation,blood samples were collected after administration of 0.08,0.25,0.5,0.75,1,2,3,4,5.5 h,and tested by HPLC.Results: The various doses of curcumin concentration-time curve is bimodal;Cmax_1 and Cmax_2 of each dose group are as follows: high-dose(0.90,1.20 mg/L),medium dose(0.43,0.46 mg/L),low dose(3.16,1.31 mg/L); AUC are 3.79,2.60,5.92 mg·h/L respectively.Cmax and AUC of low dose are greater than that of the high and medium doses.Conclusion: The Pharmacokinetics of curcumin were nonlinear process in rat,there may be the phenomenon of enterohepatic circulation.

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What this paper is about

Objective:To study the pharmacokinetics of curcumin microcystin in rats.Methods: The microcystin was orally administrated.After carotid artery cannulation,blood samples were collected after administration of 0.08,0.25,0.5,0.75,1,2,3,4,5.5 h,and tested by HPLC.Results: The various doses of curcumin concentration-time curve is bimodal;Cmax_1 and Cmax_2 of each dose group are as follows: high-dose(0.90,1.20 mg/L),medium dose(0.43,0.46 mg/L),low dose(3.16,1.31 mg/L); AUC are 3.79,2.60,5.92 mg·h/L respectively.Cmax and AUC of low dose are greater than that of the high and medium doses.Conclusion: The Pharmacokinetics of curcumin were nonlinear process in rat,there may be the phenomenon of enterohepatic circulation.

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Available abstract

Objective:To study the pharmacokinetics of curcumin microcystin in rats.Methods: The microcystin was orally administrated.After carotid artery cannulation,blood samples were collected after administration of 0.08,0.25,0.5,0.75,1,2,3,4,5.5 h,and tested by HPLC.Results: The various doses of curcumin concentration-time curve is bimodal;Cmax_1 and Cmax_2 of each dose group are as follows: high-dose(0.90,1.20 mg/L),medium dose(0.43,0.46 mg/L),low dose(3.16,1.31 mg/L); AUC are 3.79,2.60,5.92 mg·h/L respectively.Cmax and AUC of low dose are greater than that of the high and medium doses.Conclusion: The Pharmacokinetics of curcumin were nonlinear process in rat,there may be the phenomenon of enterohepatic circulation.

Key concepts: Cmax, Pharmacokinetics, Curcumin, Pharmacology, Enterohepatic circulation, Chemistry, Area under the curve, High-performance liquid chromatography

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