Comparative study of isoflurane and sevoflurane on the effects of anesthesias in abdominal surgeries with the close-loop anesthesia system

Objectives: To study the differences between sevoflurane and isoflurane in abdomen surgery anesthetized with the target-controlled close-loop anesthesia system.Methods: Forty patients (ASA I-II) were divided into sevoflurane group (n=25) and isoflurane group (n= 15).BIS value of 55 was the control variable index.The target-controlled infusion system of sevoflurane was administered for the maintenance of anesthesia in both groups after intravenous nduction. The BIS values,blood pressures,heart rates and doses of assistant drugs were recorded and analyzed.Results: No statistical difference was observed in BIS、HR and pulse pressure in two groups. During the maintenance of anesthesia, oscillations of BIS and SBP in sevoflurane group were statistically less than those in isoflurane group (P0.05). The time to open the eyes was statistically less in sevoflurane group (P0.01). Times of restlessness showed no difference in two groups. The doses of ephedrine and Ebrantil used were not statistically different. No patients reported awareness or recall of intraoperative events. Conclusion: In abdominal surgeries, anesthesia with the closed-loop anesthesia system using sevoflurane may statistically reduce restlessness and oscillations of BIS and SBP in the maintenance of anesthesia compared with isoflurane.