Celecoxib,COX-2 Inhibitor,Inhibited the Proliferation of A549 Human Lung Adenocarcinoma Cells When Combined with Cisplatin

Objective This study is designed to observe the depressive effect of celecoxib/cisplatin conbination on A549 human lung adenocarcinoma cells.Methods The depressive effect on the proliferation of A549cells was detected by MTS technique when celecoxib was conbined with cisplatin.Results Within a certain concentration,celecoxib and cisplatin was able to inhibit the proliferation of A549 cells respectively,and dose-effect relationship was detected in the process.The combination of celecoxib(0.35 mg/L) and cisplatin could enhance the depressive effect,synergistic effect or addition effect was detected in the combination when the concentration of cisplatin was more than 1 mg/L.In addition,time-effect relationship on inhibition of cells proliferation was detected in the combination within a certain concentration.Conclusion Celecoxib/cisplatin conbination could enhance the depressive effect on the proliferation of A549 human lung adenocarcinoma cells.