Follow-up of the effect of the urokinase combined with benazepril on IgA nephropathy

Objective To observe the effect of urokinase(UK) combined with angiotensin converting enzyme inhibitor (ACEI) on IgA nephropathy(IgAN). Methods Seventy-one cases with IgAN, whose renal pathologic change was no less than grade HI according to Lee's method, were divided into two groups: UK combined with ACEI (benazepril) group and ACEI (benazepril) group. The effect of two groups on IgA nephropathy was followed-up. Results (1) By the end of 12 therapeutic courses, the quantity of urine protein decreased in UK combined with ACEI group, and the level of Alb increased, which were significantly better than those in ACEI group. (2) Katafuchi IgA nephropathy score system was used to evaluate the pathologic changes of the patients. The effect of UK combined with ACEI on the patients whose glomerular scores were more than 7 was markedly better than that of ACEI group. (3)Pathologic changes in most of 10 UK + ACEI patients with the second renal biopsy were stable. Conclusions UK combined with ACEI is an effective method of treating IgAN with moderate or severe pathologic change. Glomerular score and inflammatory cells infiltration can be used as markers to observe the effect of IgAN treatment.