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2002•Chinese Journal of Current Advances in General SurgeryRequires access

Ischemic preconditioning on liver ischemic-reperfusion injury in rats

Lu Jun

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Abstract

Objective:To evaluate the influnce of ischemic preconditioning(IPC) on liver ischemic reperfusion injury(IRPI).Methods:70% hepatic ischemia-reperfusion model were performed in normal and cirrotic Wistar rats.Ischemic preconditioning , non-ischemic preconditioning and intermittent groups were compared on IRPI, by serum liver enzymes,oxidative injury,histological and ultra strcture.Results: For both normal and cirrotic liver, preconditioning attenuated IRPI, compared with non-IPC and intermittent group.In normal rats IPC 5minshowed the best results compared with IPC 10minand IPC 5min×2Conclusion:This study proves that preconditioning,as a endogernous anti-reperfusion injury mechanism,can attenuates hepatic reperfusion injury.As a new hepatic occlusion method,preconditioning will be helpful to liver surgery and liver transplantation.

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What this paper is about

Objective:To evaluate the influnce of ischemic preconditioning(IPC) on liver ischemic reperfusion injury(IRPI).Methods:70% hepatic ischemia-reperfusion model were performed in normal and cirrotic Wistar rats.Ischemic preconditioning , non-ischemic preconditioning and intermittent groups were compared on IRPI, by serum liver enzymes,oxidative injury,histological and ultra strcture.Results: For both normal and cirrotic liver, preconditioning attenuated IRPI, compared with non-IPC and intermittent group.In normal rats IPC 5minshowed the best results compared with IPC 10minand IPC 5min×2Conclusion:This study proves that preconditioning,as a endogernous anti-reperfusion injury mechanism,can attenuates hepatic reperfusion injury.As a new hepatic occlusion method,preconditioning will be helpful to liver surgery and liver transplantation.

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Available abstract

Objective:To evaluate the influnce of ischemic preconditioning(IPC) on liver ischemic reperfusion injury(IRPI).Methods:70% hepatic ischemia-reperfusion model were performed in normal and cirrotic Wistar rats.Ischemic preconditioning , non-ischemic preconditioning and intermittent groups were compared on IRPI, by serum liver enzymes,oxidative injury,histological and ultra strcture.Results: For both normal and cirrotic liver, preconditioning attenuated IRPI, compared with non-IPC and intermittent group.In normal rats IPC 5minshowed the best results compared with IPC 10minand IPC 5min×2Conclusion:This study proves that preconditioning,as a endogernous anti-reperfusion injury mechanism,can attenuates hepatic reperfusion injury.As a new hepatic occlusion method,preconditioning will be helpful to liver surgery and liver transplantation.

Key concepts: Ischemic preconditioning, Medicine, Ischemic reperfusion injury, Liver transplantation, Reperfusion injury, Ischemia, Liver injury, Anesthesia

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