Epidermal Growth Factor Receptor Gene Mutation and Its Clinical Significance in Non-small Cell Lung Cancer

The real-time fluorescence PCR were used to detect EGFR mutations in 199non-small cell lung cancer(NSCLC) tissue specimens,and the relationship between EGFR mutations and clinicopathological features were analyzed.EGFR gene mutation occurred in 56(28.1%)patients with NSCLC.Exon 19mutation occurred in 27patients(13.6%),exon 21mutation occurred in 25patients(12.6%),exon 18and exon 20mutations occurred in 2patients respectively,and 1 patient was detected with both exon 18and exon 20mutations.The EGFR mutation rate and the main mutation types of NSCLC patients in Liaoning province in China are basically identical with other regions except Guangdong and Tongling in Anhui,which was common in exon 19and 21mutations.The mutation rate of patients with adenocarcinoma and nonsmoking patients was higher,and more suitable for EGFR-TKI targeted therapy.